A clinical trial of resveratrol supplementation shows promising metabolic properties for diabetes and stopping prediabetes metabolic syndrome.
Resveratrol has been a common topic at Nutrientology. I have written about its apparent ability to act as a calorie-restriction mimetic. In other words, it causes many of the same favorable biological changes associated with a low-calorie diet. I also have posted on its ability to reduce body fat in an animal experiment, its ability to reduce insulin resistance in humans, and its ability to upregulate aiponectin. Adiponectin is an adipokine secreted by fat that is believed to play an antiobesity role.
Many of the resveratrol studies have been done on animals or cell cultures, but another new study has looked at the effect of resveratrol on humans. It appears that small daily doses of resveratrol could improve the metabolism of obese men to similar levels of those on a strict low-calorie diet.
The study, published in Cell Metabolism (Nov. 2011), reports that obese men receiving a daily dietary supplement containing 150 milligrams of resveratrol for 30 days improved their energy metabolism with similar metabolic changes seen in people on a severe calorie restriction diet.
During the trial the team measured metabolic rate, fat storage, fat burning, blood sugar levels and blood pressure, in order to assess any change in metabolism due to the resveratrol. The authors reported that the resveratrol supplement lowered metabolism and improved measures of metabolism and overall health.
The researchers believe the results demonstrate that resveratrol affects energy metabolism through activation of the ‘AMPK-SIRT1’ pathway – resulting in a decrease of blood glucose and insulin levels, less fat storage in the liver, enhancement of the mitochondrial function and reduction of levels of inflammation markers in the blood.
The study was small only involving 11 men, but this interesting compound certainly warrants further research especially pertaining to helping diabetes, stopping pre-diabetes and reducing the obesity that often accompanies these metabolic health problems.