The benefits of resveratrol observed in animal experiments is also starting to be observed in human experiments involving people with type 2 diabetes and pre-diabetes metabolic syndrome using resveratrol as a diet supplement.
The researchers in this pilot study set out to determine if there was any merit in pursuing a larger study by testing the effects of 1-2 g of resveratrol per day on a small group of overweight seniors with impaired glucose tolerance. Impaired glucose tolerance means that their bodies cannot reduce blood sugar (glucose) levels well, and blood sugar levels therefore stay high as opposed to being taken up by the muscle, liver and fat cells. This is the definition of prediabetes. If you wish to stop prediabetes, you need to have a metabolism that can tolerate and process carbohydrate foods better. Not only did the researchers look at blood sugar glucose metabolism, they also included blood circulation effects of resveratrol.
Ten people aged 72 ± 3 years with reduced glucose tolerance were enrolled in the 4-week study. After eating a meal (110 g carbohydrate, 20 g protein, 20 g fat), the researchers measured various glucose metabolism markers. The function of the cells that line the blood vessels, known as endothelial cells, were also tested.
The results did not differ by dose, so the data was combined for analysis. They concluded:
At doses between 1 and 2 g/day, resveratrol improves insulin sensitivity and post meal plasma glucose in subjects with impaired glucose tolerance. These preliminary findings support the conduct of larger studies to further investigate the effects of resveratrol on metabolism and vascular function.
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