New Acai Compound Acts As Potent Anti-Inflammatory

The potential health benefits of acai as a pre diabetes diet supplement may be linked to a potent anti-inflammatory compound recently found in acai extract called velutin.

acai pre diabetes diet supplement and metabolic syndrome prediabetes managementI have previously posted on the diabetes and cholesterol-lipid benefits of Acai. Research as previously showed that Acai has strong antioxidant properties, and that dietary antioxidants have been associated with a lower incidence of various cardiovascular diseases including coronary artery disease and stroke.

A study published in The Journal of Nutritional Biochemistry evaluated the anti-inflammatory effects of velutin and showed that this flavonoid compound has an even stronger anti-inflammatory effect than other more well-known anti-inflammatory flavonoids luteolin, apigenin and chrysoeriol.

The researchers isolated velutin from acai fruit pulp and examined its effects on a certain type of white blood cell. These cells, called macrophages, were exposed to an inflammation producing lipopolysaccharide. Lipopolysaccharides (LPS) are found in the membrane, or “skin,” of certain bacteria and act as toxins causing a strong inflammatory immune response.

The researchers evaluated the effect of LPS exposure on the macrophage cells’ production of inflammatory compounds known as tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6) in the presence or absence of velutin, and compared this reaction with other flavones with similar chemical structures (luteolin, apigenin and chrysoeriol).

Velutin was found to be the most potent for reducing the production of both TNF-alpha and IL-6.

Velutin can be classed as a new strong anti-inflammatory flavonoid in the broader class of plant compounds known as polyphenols.

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About Robert Creighton

Dr. Creighton is a podiatrist and foot surgeon with over 26 years in podiatric practice treating thousands of patients afflicted with the physiological, physical, and psychological side effects and complications of diabetes and pre-diabetes metabolic syndrome. He believes these disorders present a pressing public health concern that need to be more actively addressed in a multidisciplinary way. Dr. Creighton graduated from what is now the Temple University School of Podiatric Medicine after receiving his undergraduate degree in Biology. He is certified by the American Board of Foot and Ankle Surgery, a member of the American Public Health Association, an American College of Sports Medicine certified personal trainer and a Member of the American Nutrition Association.

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